Structure guided generation of thieno[3,2-d]pyrimidin-4-amine Mycobacterium tuberculosis bd oxidase inhibitors-Reference-Cited by-同舟云学术

Structure guided generation of thieno[3,2-d]pyrimidin-4-amine Mycobacterium tuberculosis bd oxidase inhibitors

Published:2021 Issue:1 Volume:12 Page:73-77
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Hopfner Sarah M.¹²³⁴^ORCID,Lee Bei Shi⁵⁶⁷^ORCID,Kalia Nitin P.⁸⁶⁷,Miller Marvin J.¹⁹¹⁰⁴^ORCID,Pethe Kevin⁵⁶⁷^ORCID,Moraski Garrett C.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry

2. Montana State University

3. Bozeman

4. USA

5. Lee Kong Chian School of Medicine

6. Nanyang Technological University

7. Singapore

8. School of Biological Sciences

9. University of Notre Dame

10. Indiana 46556

Abstract

Screening for inhibitors of Cyt-bd in Mycobacterium bovis BCG and Mycobacterium tuberculosis revealed thieno[3,2-d]pyrimidine (7) which through SAR efforts resulted in an improved analogue (19) of this scaffold.

Funder

National Institute of Allergy and Infectious Diseases

National Research Foundation Singapore

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/MD/D0MD00398K

Reference21 articles.

1. Global tuberculosis report 2018 , World Health Organization , Geneva , 2018 , Licence: CC BY-NCSA 3.0 IGO

2. A. E. McDonald and G. C.Vanlerberghe , in Structural Basis of Biological Energy Generation , ed. M. F. Hohmann-Marriott , Springer , Dordrecht , 2014 , vol. 39 , pp. 277–293

3. Targeting Energy Metabolism in Mycobacterium tuberculosis , a New Paradigm in Antimycobacterial Drug Discovery

4. Nonreplicating Persistence of Mycobacterium Tuberculosis

5. Reduction of Clofazimine by Mycobacterial Type 2 NADH:Quinone Oxidoreductase

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