Enhanced podocyte differentiation and changing drug toxicity sensitivity through pressure-controlled mechanical filtration stress on a glomerulus-on-a-chip-Reference-Cited by-同舟云学术

Enhanced podocyte differentiation and changing drug toxicity sensitivity through pressure-controlled mechanical filtration stress on a glomerulus-on-a-chip

Published:2023 Issue:3 Volume:23 Page:437-450
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Doi Kotaro¹^ORCID,Kimura Hiroshi²^ORCID,Kim Soo Hyeon¹^ORCID,Kaneda Shohei³,Wada Takehiko⁴,Tanaka Tetsuhiro⁵,Shimizu Akira⁶,Sano Takanori¹,Chikamori Masamichi¹^ORCID,Shinohara Marie¹^ORCID,Matsunaga Yukiko T.¹^ORCID,Nangaku Masaomi⁷,Fujii Teruo⁸^ORCID

Affiliation:

1. Institute of Industrial Science, The University of Tokyo, Tokyo, Japan

2. Micro/Nano Technology Center, Tokai University, Kanagawa, Japan

3. Department of Mechanical Systems Engineering, Faculty of Engineering, Kogakuin University, Tokyo, Japan

4. Division of Nephrology, Endocrinology and Metabolism, Tokai University School of Medicine, Kanagawa, Japan

5. Department of Nephrology, Rheumatology and Endocrinology, Tohoku University Graduate School of Medicine, Miyagi, Japan

6. Department of Analytic Human Pathology, Nippon Medical School, Tokyo, Japan

7. Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan

8. The University of Tokyo, Tokyo, Japan

Abstract

The development of a filtration flow device system with precisely controlled pressure revealed the mechanobiology of filtration flow to podocytes regarding morphological and gene expression maturation and increased sensitivity to toxic drugs.

Funder

Japan Society for the Promotion of Science

Japan Agency for Medical Research and Development

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2023/LC/D2LC00941B

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