From at-line to online NMR: coupling probe-based autosampler with benchtop NMR-Reference-Cited by-同舟云学术

From at-line to online NMR: coupling probe-based autosampler with benchtop NMR

Published:2023 Issue:9 Volume:8 Page:2270-2274
ISSN:2058-9883
Container-title:Reaction Chemistry & Engineering
language:en
Short-container-title:React. Chem. Eng.

Author:

Ji Yining¹^ORCID,Lin Zhihao²,Lawson Latevi²,Lévesque François³,Foley David A.¹^ORCID,Espina Robert⁴,Robert Hector⁴

Affiliation:

1. Analytical Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, USA

2. Analytical Chemistry in Development and Supply, Merck & Co., Inc., Rahway, New Jersey 07065, USA

3. Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, USA

4. Magritek Inc., Malvern, Pennsylvania 19355, USA

Abstract

The integration of benchtop NMR with a probe-based autosampler enables automated sampling and real-time measurement of reaction samples, as well as verification and calibration of spectroscopic methods.

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RE/D3RE00194F

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4. Inline, online, and at-line measurements are made directly in the process, at a branch of the process, and in the lab next door, respectively

5. Comparison of in-line NIR, Raman and UV-visible spectrometries, and at-line NMR spectrometry for the monitoring of an esterification reaction

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