Effects of 2-substitution on 14-epi-19-nortachysterol-mediated biological events: based on synthesis and X-ray co-crystallographic analysis with the human vitamin D receptor

Author:

Sawada Daisuke1234,Kakuda Shinji5674,Takeuchi Akiko5674,Kawagoe Fumihiro1234,Takimoto-Kamimura Midori5674,Kittaka Atsushi1234ORCID

Affiliation:

1. Faculty of Pharmaceutical Sciences

2. Teikyo University

3. Tokyo 173-8605

4. Japan

5. Teijin Institute for Bio-medical Research

6. Teijin Pharma Ltd

7. Hino

Abstract

Interaction of the 2-functional group of tachysterol analogs in the vitamin D receptor ligand binding domain: X-ray co-crystallographic analysis.

Funder

Japan Society for the Promotion of Science

Uehara Memorial Foundation

Takeda Science Foundation

Japan Agency for Medical Research and Development

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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