A near-infrared fluorescent probe for imaging peroxynitrite levels in paw edema mice and drug evaluation

Author:

Hu Ling1,Chen Si-Si1,Zhang Hui1,Chao Jing-Jing1,Peng Zhen-Zhen1,Mao Guo-Jiang2,Hu Liufang1,Ouyang Juan1,Min Anjie3,Li Chun-Yan1ORCID

Affiliation:

1. Key Laboratory for Green Organic Synthesis and Application of Hunan Province, Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, Hunan Provincial University Key Laboratory for Environmental and Ecological Health, College of Chemistry, Xiangtan University, Xiangtan, 411105, P. R. China

2. Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, 453007, P. R. China

3. Department of Oral and Maxillofacial Surgery, Center of Stomatology, Research Center of Oral and Maxillofacial Tumor, Insititute of Oral Cancer and Precancerous Lesions, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, P. R. China

Abstract

A near-infrared fluorescent probe (TX-P) for detecting peroxynitrite is constructed. The probe has long emission and large Stokes shift. TX-P can be used to visualize ONOO in cells, image ONOO in paw edema mice and evaluate anti-inflammatory drugs.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Hunan Province

Publisher

Royal Society of Chemistry (RSC)

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