A three-in-one-bullet for oesophageal cancer: replication fork collapse, spindle attachment failure and enhanced radiosensitivity generated by a ruthenium(ii) metallo-intercalator
Author:
Affiliation:
1. CRUK/MRC Oxford Institute for Radiation Oncology
2. Department of Oncology
3. University of Oxford
4. Oxford
5. UK
6. Department of Chemistry
7. University of Sheffield
8. Sheffield
9. Department of Biomedical Science
Abstract
[Ru(phen)2(tpphz)]2+ simultaneously inhibits DNA replication, blocks mitosis and enhances DNA-damaging ionising radiation in oesophageal cancer cells.
Funder
Cancer Research UK
Medical Research Council
Engineering and Physical Sciences Research Council
Leverhulme Trust
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2018/SC/C7SC03712K
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5. Oesophageal cancer
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