Mitochondria-targeted aggregation induced emission theranostics: crucial importance of in situ activation-Reference-Cited by-同舟云学术

Mitochondria-targeted aggregation induced emission theranostics: crucial importance of in situ activation

Published:2016 Issue:9 Volume:7 Page:6050-6059
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Shin Weon Sup¹²³⁴,Lee Min-Goo⁵²³⁴,Verwilst Peter¹²³⁴^ORCID,Lee Joung Hae⁶⁷⁴,Chi Sung-Gil⁵²³⁴^ORCID,Kim Jong Seung¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. Korea University

3. Seoul

4. Korea

5. School of Life Sciences and Biotechnology

6. Korea Research Institute of Standards and Science

7. Daejeon 305-600

Abstract

A mitochondria targeted AIE fluorophore was further decorated with an NQO1 cleavable masking unit and showed selective targeting to and activation in cancer cells resulting in bright AIE fluorescence and apoptosis triggered by mitochondrial dysfunction.

Funder

National Research Foundation of Korea

Korea University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/SC/C6SC02236G

Reference49 articles.

1. Novel cytotoxic drugs: Old challenges, new solutions

2. Cancer drug resistance: an evolving paradigm