A highly selective iron oxide-based imaging nanoparticle for long-term monitoring of drug-induced tumor cell apoptosis-Reference-Cited by-同舟云学术

A highly selective iron oxide-based imaging nanoparticle for long-term monitoring of drug-induced tumor cell apoptosis

Published:2021 Issue:2 Volume:9 Page:471-481
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Lin Guanyou¹²³⁴,Mu Qingxin⁵²³⁴^ORCID,Revia Richard¹²³⁴^ORCID,Stephen Zachary¹²³⁴^ORCID,Jeon Mike¹²³⁴,Zhang Miqin¹²³⁴⁶^ORCID

Affiliation:

1. Department of Materials Sciences and Engineering

2. University of Washington

3. Seattle

4. USA

5. Department of Pharmaceutics

6. Department of Neurological Surgery

Abstract

PSA was conjugated onto IONP by first covalently linking Neu onto a 10 nm IONP core and then attaching PSA to neu via biotin–avidin interaction. When applied in vivo, IONP-Neu-PSA-Cy5.5 produced persistent near-IR signal specifically for monitoring tumor apoptosis.

Funder

National Institutes of Health

National Science Foundation

W. M. Keck Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/BM/D0BM00518E

Reference51 articles.

1. Longitudinal Bioluminescence Imaging of the Dynamics of Doxorubicin Induced Apoptosis