A second generation of 1,2,4-oxadiazole derivatives with enhanced solubility for inhibition of 3-hydroxykynurenine transaminase (HKT) from Aedes aegypti-Reference-Cited by-同舟云学术

A second generation of 1,2,4-oxadiazole derivatives with enhanced solubility for inhibition of 3-hydroxykynurenine transaminase (HKT) from Aedes aegypti

Published:2021 Issue:2 Volume:12 Page:222-236
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Maciel Larissa G.¹²³⁴,Barbosa Andrey da S.¹²³⁴^ORCID,de Alencar-Filho Edilson B.⁵⁶⁷⁴,Soares Thereza A.¹²³⁴^ORCID,dos Anjos Janaína V.¹²³⁴^ORCID

Affiliation:

1. Department of Fundamental Chemistry

2. Federal University of Pernambuco (UFPE)

3. Recife – PE

4. Brazil

5. College of Pharmacy

6. Federal University of San Francisco Valley (UNIVASF)

7. Petrolina – PE

Abstract

Water-soluble oxadiazole-based HKT inhibitor library, comprising a new class of compounds for control of Aedes aegypti dissemination, act as competitive HKT enzyme inhibitors, promoting accumulation of the toxic metabolite 3-hydroxykynurenine in insect organism.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Fundação de Amparo à Pesquisa do Estado de São Paulo

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/MD/D0MD00305K

Reference50 articles.