Apple peel polyphenol alleviates antibiotic-induced intestinal dysbiosis by modulating tight junction proteins, the TLR4/NF-κB pathway and intestinal flora

Author:

He Ziqian1ORCID,Deng Na2ORCID,Zheng Bisheng13,Gu Yingjie1,Chen Jian1,Li Tong4,Liu Rui Hai4,Yuan Ling5,Li Wenzhi5

Affiliation:

1. School of Food Science and Engineering, South China University of Technology, 381 Wushan Road, Guangzhou, Guangdong 510640, China

2. School of Food Science and Bioengineering, Changsha University of Science & Technology, Changsha 410114, China

3. Research Institute for Food Nutrition and Human Health, Guangzhou, 510640 China

4. Department of Food Science, Stocking Hall, Cornell University, Ithaca, NY 14853, USA

5. Guangdong ERA Food & Life Health Research Institute, Guangzhou, Guangdong 510530, China

Abstract

After antibiotic-induced intestinal dysbiosis, APP treatment can strengthen the biological, mechanical and immune barriers of the intestine by regulating its flora and inflammatory factors.

Funder

Higher Education Discipline Innovation Project

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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