Melting point–solubility–structure correlations in chiral and racemic model cocrystals

Author:

Kilinkissa Ornella E. Y.1234,Govender Krishna K.56748ORCID,Báthori Nikoletta B.1234ORCID

Affiliation:

1. Department of Chemistry

2. Cape Peninsula University of Technology

3. Cape Town

4. South Africa

5. Department of Chemical Sciences

6. University of Johannesburg

7. Johannesburg

8. Council for Scientific and Industrial Research

Abstract

Comparison of chiral and racemic binary cocrystals showed that the chiral building block limits the formation of certain intermolecular interactions, decreases the packing efficiency, lowers the melting point and increases aqueous solubility.

Funder

Cape Peninsula University of Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Materials Science,General Chemistry

Reference46 articles.

1. Supramolecular Synthons in Crystal Engineering—A New Organic Synthesis

2. A. Nangia and G. R.Desiraju , Supramolecular Synthons and Pattern Recognition, in Design of Organic Solids. Topics in Current Chemistry , ed. E. Weber , et al. , Springer , Berlin, Heidelberg , 1998 , vol. 198

3. Fine tuning of crystal architecture by intermolecular interactions: synthon engineering

4. G. R. Desiraju , Crystal Engineering: The design of Organic Solids , Elsevier , Amsterdam , 1989

5. Supramolecular Structures – Reason and Imagination

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