A dual DNA-binding conjugate that selectively recognizes G-quadruplex structures

Author:

Ooga Mitsuharu1,Sahayasheela Vinodh J.1ORCID,Hirose Yuki1ORCID,Sasaki Daisuke1,Hashiya Kaori1,Bando Toshikazu1,Sugiyama Hiroshi2ORCID

Affiliation:

1. Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan

2. Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Yoshida-ushinomiyacho, Sakyo-ku, Kyoto 606-8501, Japan

Abstract

The hybrid compounds we synthesized can recognize both a G-quadruplex (G4) structure and its proximal duplex region concurrently, which enables the selective recognition of a specific G4.

Funder

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

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