Ergothioneine suppresses hepatic stellate cell activation <i>via</i> promoting Foxa3-dependent potentiation of the Hint1/Smad7 cascade and improves CCl<sub>4</sub>-induced liver fibrosis in mice-Reference-Cited by-同舟云学术

Ergothioneine suppresses hepatic stellate cell activation via promoting Foxa3-dependent potentiation of the Hint1/Smad7 cascade and improves CCl₄-induced liver fibrosis in mice

Published:2023 Issue:23 Volume:14 Page:10591-10604
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Shu Guangwen¹,Lei Xiao¹,Li Guangqiong¹,Zhang Tiantian¹,Wang Chuo¹,Song Anning¹,Yu Huifan²^ORCID,Wang Xiaoming³,Deng Xukun¹^ORCID

Affiliation:

1. School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan, Hubei, China

2. Hubei Key Laboratory of Wudang Local Chinese Medicine Research, School of Pharmaceutical Sciences, Hubei University of Medicine, Shiyan, Hubei, China

3. State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China

Abstract

EGT is a bioactive compound derived from certain edible mushrooms. Here, we showed that EGT inhibits HSC activation and improves CCl4-induced mouse liver fibrosis by promoting nuclear translocation of Foxa3 in HSCs to potentiate the Hint1/Smad7 axis.

Funder

National Ethnic Affairs Commission of the People's Republic of China

Hubei Key Laboratory of Wudang Local Chinese Medicine Research

South-Central University for Nationalities

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/FO/D3FO03643J

Reference59 articles.

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3. Hepatic stellate cells as key target in liver fibrosis

4. Mitochondrial folate metabolism–mediated α-linolenic acid exhaustion masks liver fibrosis resolution

5. Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling

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