Intestinal microbiome and metabolome analyses reveal metabolic disorders in the early stage of renal transplantation

Author:

Ma Chiyu12,He Jingquan2,Lai Liusheng1,Chen Yumei2,Xue Wen1,Chen Jieping2,Dai Weier3,Tang Donge12,Yan Qiang1,Dai Yong12ORCID

Affiliation:

1. Guangxi Key Laboratory of Metabolic Disease Research, Nephrology Department, Central Laboratory of Guilin, NO. 924 Hospital, Guilin, 541002, China

2. Clinical Medical Research Center, The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen People's Hospital, Shenzhen 518020, China

3. College of Natural Science, University of Texas at Austin, Austin, Texas, 78712, USA

Abstract

This study reveals the potential relationship between gut microbes and metabolic pathways in kidney transplant patients. The enriched Enterococcus in transplant patients may be related to the accumulation of nephrotoxic molecules.

Funder

Natural Science Foundation of Guangxi Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Genetics,Molecular Biology,Biochemistry

Reference45 articles.

1. A comparative analysis of survival of patients on dialysis and after kidney transplantation

2. OPTN/SRTR 2015 Annual Data Report: Kidney

3. E.Machtejevas , K. K.Unger and R.Ditz , Multidimensional Column Liquid Chromatography (LC) in Proteomics – Where Are We Now? , 2006 , pp. 788–795

4. Current Progress in computational metabolomics

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