Triple action Pt(iv) derivatives of cisplatin: a new class of potent anticancer agents that overcome resistance-Reference-Cited by-同舟云学术

Triple action Pt(iv) derivatives of cisplatin: a new class of potent anticancer agents that overcome resistance

Published:2018 Issue:18 Volume:9 Page:4299-4307
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Petruzzella Emanuele¹²³⁴⁵^ORCID,Sirota Roman¹²³⁴⁵,Solazzo Irene⁶⁷⁸⁹,Gandin Valentina⁶⁷⁸⁹^ORCID,Gibson Dan¹²³⁴⁵^ORCID

Affiliation:

1. Institute for Drug Research

2. School of Pharmacy

3. The Hebrew University

4. Jerusalem

5. Israel

6. Dipartimento di Scienze del Farmaco

7. Università di Padova

8. Padova

9. Italy

Abstract

A series of triple action Pt(iv) prodrugs was designed to test the hypothesis that multi-action compounds, where each bioactive moiety intervenes in several cellular processes, might be more effective than a single agent at killing cancer cells.

Funder

Israel Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/SC/C8SC00428E

Reference41 articles.

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4. Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects

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