Nitrogen positional scanning in tetramines active against HIV-1 as potential CXCR4 inhibitors-Reference-Cited by-同舟云学术

Nitrogen positional scanning in tetramines active against HIV-1 as potential CXCR4 inhibitors

Published:2016 Issue:4 Volume:14 Page:1455-1472
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Puig de la Bellacasa Raimon¹²³⁴⁵,Gibert Albert¹²³⁴⁵,Planesas Jesús M.¹²³⁴⁵,Ros-Blanco Laia¹²³⁴⁵,Batllori Xavier¹²³⁴⁵,Badía Roger⁶⁷⁸⁹⁵,Clotet Bonaventura⁶⁷⁸⁹⁵,Esté José⁶⁷⁸⁹⁵,Teixidó Jordi¹²³⁴⁵,Borrell José I.¹²³⁴⁵

Affiliation:

1. Grup d'Enginyeria Molecular

2. Institut Químic de Sarrià

3. Universitat Ramon Llull

4. E-08017 Barcelona

5. Spain

6. AIDS Research Institute IrsiCaixa

7. Hospital Universitari Germans Trias i Pujol

8. Universitat Autonoma de Barcelona

9. 08916 Badalona

Abstract

The paradigm, derived from bicyclams, by which it is necessary to use the p-phenylene moiety as the central core in order to achieve high HIV-1 antiviral activities has been reexamined for structures 4.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C5OB02419F

Reference27 articles.

1. AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor

2. Plerixafor

3. http://pubchem.ncbi.nlm.nih.gov/compound/Plerixafor

4. AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor

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