Structure–activity relationship studies on 2,5,6-trisubstituted benzimidazoles targeting Mtb-FtsZ as antitubercular agents-Reference-Cited by-同舟云学术

Structure–activity relationship studies on 2,5,6-trisubstituted benzimidazoles targeting Mtb-FtsZ as antitubercular agents

Published:2021 Issue:1 Volume:12 Page:78-94
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Haranahalli Krupanandan¹²³⁴⁵,Tong Simon⁵²³⁴,Kim Saerom⁵²³⁴,Awwa Monaf⁵²³⁴,Chen Lei⁵²³⁴,Knudson Susan E.⁶⁷⁸⁴,Slayden Richard A.⁶⁷⁸⁴,Singleton Eric⁹¹⁰¹¹¹²⁴,Russo Riccardo⁹¹⁰¹¹¹²⁴,Connell Nancy⁹¹⁰¹¹¹²⁴,Ojima Iwao¹²³⁴⁵^ORCID

Affiliation:

1. Institute of Chemical Biology and Drug Discovery

2. Stony Brook University

3. Stony Brook

4. USA

5. Department of Chemistry

6. Department of Microbiology, Immunology and Pathology

7. Colorado State University

8. Fort Collins

9. Department of Medicine

10. Center for Emerging and Re-emerging Pathogens

11. Rutgers University

12. Newark

Abstract

Filamenting temperature sensitive protein Z (FtsZ) is an essential bacterial cell division protein and a promising target for the development of new antibacterial therapeutics.

Funder

National Institute of Allergy and Infectious Diseases

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/MD/D0MD00256A

Reference31 articles.

1. Global Tuberculosis Report , W.H.O , 2019

2. S. J. Berthel , C. B.Cooper and N.Fotouhi , in Annual Reports in Medicinal Chemistry , Academic Press , 2019 , 10.1016/bs.armc.2019.05.004

3. Risk Assessment of Tuberculosis in Immunocompromised Patients. A TBNET Study