Establishing the selective phospholipid membrane coordination, permeation and lysis properties for a series of ‘druggable’ supramolecular self-associating antimicrobial amphiphiles-Reference-Cited by-同舟云学术

Establishing the selective phospholipid membrane coordination, permeation and lysis properties for a series of ‘druggable’ supramolecular self-associating antimicrobial amphiphiles

Published:2022 Issue:33 Volume:13 Page:9761-9773
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Boles Jessica E.¹²,Bennett Charlotte³,Baker Jennifer³,Hilton Kira L. F.¹,Kotak Hiral A.⁴^ORCID,Clark Ewan R.¹^ORCID,Long Yifan⁴,White Lisa J.¹,Lai Hin Yuk⁴,Hind Charlotte K.⁵,Sutton J. Mark⁵,Garrett Michelle D.²,Cheasty Anne³⁶,Ortega-Roldan Jose L.²^ORCID,Charles Mark³,Haynes Cally J. E.⁴^ORCID,Hiscock Jennifer R.¹^ORCID

Affiliation:

1. School of Chemistry and Forensics, University of Kent, Canterbury, CT2 7NH, UK

2. School of Biosciences, University of Kent, Canterbury, CT2 7NJ, UK

3. Cancer Research Horizons, 2 Redman Place, London, E20 1JQ, UK

4. Chemistry Department, UCL, 20 Gordon Street, London WC1H 0AJ, UK

5. Research and Evaluation, Porton Down, UKHSA, Porton Down, Salisbury SP4 0JG, UK

6. Exscientia, The Schrödinger Building, Heatley Road, Oxford Science Park, Oxford, OX4 4GE, UK

Abstract

A combination of computational and synthetic phospholipid vesicle/nanodisc assays are used to investigate the mode of action for a class of antimicrobial agents, while a range of DMPK studies establish agent druggability.

Funder

University of Kent

Engineering and Physical Sciences Research Council

UK Research and Innovation

Tropical Biology Association

University College London

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC02630A