Introducing a squaramide-based self-immolative spacer for controlled drug release-Reference-Cited by-同舟云学术

Introducing a squaramide-based self-immolative spacer for controlled drug release

Published:2021 Issue:22 Volume:57 Page:2736-2739
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Ximenis Marta¹²³⁴,Sampedro Angel¹²³⁴,Martínez-Crespo Luis¹²³⁴^ORCID,Ramis Guillem⁵⁶²⁷⁴,Orvay Francisca¹²³⁴^ORCID,Costa Antonio¹²³⁴^ORCID,Rotger Carmen¹²³⁴^ORCID

Affiliation:

1. Universitat de les Illes Balears

2. Cra. Valldemossa Km 7.5

3. Palma de Mallorca 07122

4. Spain

5. Institut Universitari d’Investigació en Ciències de la Salut (IUNICS)

6. Universitat de les Illes Balears, and Institut d’Investigació Sanitària Illes Balears (IdISBa)

7. Palma

Abstract

Herein we report the design, synthesis and assessment of the first example of a squaramide-based self-immolative system triggered by an enzymatic reduction.

Funder

Secretaría de Estado de Investigación, Desarrollo e Innovación

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CC/D0CC07683J

Reference33 articles.

1. Self-assembling prodrugs

2. Prodrugs: Some Thoughts and Current Issues

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4. Prodrugs in medicinal chemistry and enzyme prodrug therapies

5. Prodrugs: design and clinical applications

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