Natural product scaffolds as inspiration for the design and synthesis of 20S human proteasome inhibitors-Reference-Cited by-同舟云学术

Natural product scaffolds as inspiration for the design and synthesis of 20S human proteasome inhibitors

Published:2020 Issue:5 Volume:1 Page:305-332
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Hubbell Grace E.¹,Tepe Jetze J.¹^ORCID

Affiliation:

1. Department of Chemistry, Michigan State University, East Lansing, MI 48823, USA

Abstract

The 20S proteasome is a valuable target for the treatment of a number of diseases including cancer, neurodegenerative disease, and parasitic infection.

Funder

National Institute on Aging

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CB/D0CB00111B

Reference265 articles.

1. THE UBIQUITIN SYSTEM

2. Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.

3. Structural Features of the 26 S Proteasome Complex

4. Crystal Structure of the 20 S Proteasome from the Archaeon T. acidophilum at 3.4 Å Resolution

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