All-in-one disulfide bridging enables the generation of antibody conjugates with modular cargo loading-Reference-Cited by-同舟云学术

All-in-one disulfide bridging enables the generation of antibody conjugates with modular cargo loading

Published:2022 Issue:30 Volume:13 Page:8781-8790
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Dannheim Friederike M.¹^ORCID,Walsh Stephen J.¹²^ORCID,Orozco Carolina T.¹^ORCID,Hansen Anders Højgaard¹³,Bargh Jonathan D.¹^ORCID,Jackson Sophie E.¹^ORCID,Bond Nicholas J.⁴,Parker Jeremy S.⁵^ORCID,Carroll Jason S.²,Spring David R.¹^ORCID

Affiliation:

1. Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK

2. Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, CB2 0RE, UK

3. Department of Chemistry, Technical University of Denmark (DTU), 2800 Kgs. Lyngby, Denmark

4. Analytical Sciences, Biopharmaceutical Development, R&D, AstraZeneca, Granta Park, Cambridge, CB21 6GH, UK

5. Early Chemical Development, Pharmaceutical Development, R&D, AstraZeneca, Macclesfield, SK10 2NA, UK

Abstract

Tetra-divinylpyrimidine (TetraDVP) linkers offer a method for the generation of antibody conjugates with modular cargo loading and excellent stability via all-in-one disulfide bridging.

Funder

Engineering and Physical Sciences Research Council

Biotechnology and Biological Sciences Research Council

Cancer Research UK

UK Research and Innovation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC02198F

Reference59 articles.