Synthesis of withasomnine and pyrazole derivatives via intramolecular dehydrogenative cyclization, as well as biological evaluation of withasomnine-based scaffolds-Reference-Cited by-同舟云学术

Synthesis of withasomnine and pyrazole derivatives via intramolecular dehydrogenative cyclization, as well as biological evaluation of withasomnine-based scaffolds

Published:2018 Issue:5 Volume:5 Page:850-854
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Xia Tingting¹²³⁴⁵,Hu Zhenyi¹²³⁴⁵,Ji Wenzhi¹²³⁴⁵,Zhang Shujie¹²³⁴⁵,Shi Hui¹²³⁴⁵,Liu Chenguang¹²³⁴⁵,Pang Bo⁶⁷⁸⁹⁵,Liu Guijian⁶⁷⁸⁹⁵,Liao Xuebin¹²³⁴⁵^ORCID

Affiliation:

1. School of Pharmaceutical Sciences

2. Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases

3. Tsinghua University

4. Beijing 100084

5. China

6. Clinical laboratory

7. Guang'anmen Hospital

8. China Academy of Chinese Medical Sciences

9. Beijing

Abstract

Synthesis of a withasomnine-inspired library which shows anticancer reactivities and COX-2 inhibition via an intramolecular dehydrogenative cyclization process.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/QO/C7QO00847C

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3. Withasomnine. A pyrazole alkaloid from Withania somnifera Dun.

4. A Novel and Practical One Step Synthesis of 5,6-Dihydro -3-Phenyl-4H-Pyrrolo (1,2-b) Pyrazole (Withasomnine)

5. New synthetic route to the alkaloid withasomnine by ring transformation of a functionalized cyclopropanol via the parent pyrrolo[1,2-b]pyrazole

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