One-pot synthesis of a hydrogen peroxide-selective fluorogenic probe and its application in Parkinson's diseasein vitroandvivomodels-Reference-Cited by-同舟云学术

One-pot synthesis of a hydrogen peroxide-selective fluorogenic probe and its application in Parkinson's diseasein vitroandvivomodels

Published:2020 Issue:5 Volume:1 Page:1448-1454
ISSN:2633-5409
Container-title:Materials Advances
language:en
Short-container-title:Mater. Adv.

Author:

Lu Yao¹²³⁴,Peng Bo⁵⁶⁷⁸⁹,Qiu Xinghan¹²³⁴,Li Xin⁵⁶⁷⁸⁹,Li Zheng¹²³⁴,Zhang Duoteng¹²³⁴,Ji Wenhui¹²³⁴,Fang Bin⁵⁶⁷⁸⁹,Wu Qiong¹²³⁴,Zhang Chengwu¹²³⁴,Li Lin¹²³⁴^ORCID,Huang Wei¹²³⁴⁵

Affiliation:

1. Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM)

2. Nanjing Tech University (Nan-jingTech)

3. Nanjing

4. P. R. China

5. Frontiers Science Center for Flexible Electronics

6. Xi’an Institute of Flexible Electronics (IFE) and Xi’an Institute of Biomedical Materials & Engineering

7. Northwestern Polytechnical University

8. Xi’an 710072

9. China

Abstract

An abnormal level of hydrogen peroxide in neurons is strongly implicated in the progression of Parkinson’s disease. A one-pot multicomponent reaction has been utilized to synthesise phosphate ester-based probe for imaging of H₂O₂ in living cells andDrosophilaPD model.

Funder

National Natural Science Foundation of China

Shanxi Provincial Key Research and Development Project

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

Microbiology

Link

http://pubs.rsc.org/en/content/articlepdf/2020/MA/D0MA00318B

Reference46 articles.

1. Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities