pHLIP-modified magnetic nanoparticles for targeting acidic diseased tissue-Reference-Cited by-同舟云学术

pHLIP-modified magnetic nanoparticles for targeting acidic diseased tissue

Published:2016 Issue:65 Volume:6 Page:60196-60199
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Demin A. M.¹²³,Pershina A. G.⁴⁵³⁶⁵,Nevskaya K. V.⁴⁵³,Efimova L. V.⁴⁵³,Shchegoleva N. N.⁷²³,Uimin M. A.⁷²³,Kuznetsov D. K.⁸⁹¹⁰²³,Shur V. Ya.⁸⁹¹⁰²³,Krasnov V. P.¹²³,Ogorodova L. M.⁴⁵³

Affiliation:

1. Postovsky Institute of Organic Synthesis of RAS (Ural Branch)

2. Yekaterinburg

3. Russia

4. Siberian State Medical University

5. Tomsk

6. Russian National Research Tomsk Polytechnic University

7. Mikheev Institute of Metal Physics of RAS (Ural Branch)

8. Ural Centre for Shared Use “Modern Nanotechnology”

9. Institute of Natural Sciences

10. Ural Federal University

Abstract

Covalent immobilization of a pH-low insertion peptide (pHLIP) onto Fe₃O₄ magnetic nanoparticles was carried out resulting in the formation of MRI-visible material able to specifically accumulate in acidic damaged tissue.

Funder

Russian Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA13178F

Reference21 articles.

1. Targeting acidity in diseased tissues: Mechanism and applications of the membrane-inserting peptide, pHLIP

2. pH-(low)-insertion-peptide (pHLIP) translocation of membrane impermeable phalloidin toxin inhibits cancer cell proliferation

3. MicroRNA silencing for cancer therapy targeted to the tumour microenvironment