Complexation of clofazimine by macrocyclic cucurbit[7]uril reduced its cardiotoxicity without affecting the antimycobacterial efficacy-Reference-Cited by-同舟云学术

Complexation of clofazimine by macrocyclic cucurbit[7]uril reduced its cardiotoxicity without affecting the antimycobacterial efficacy

Published:2016 Issue:31 Volume:14 Page:7563-7569
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Li Shengke¹²³⁴⁵,Chan Judy Yuet-Wa¹²³⁴⁵,Li Yan⁶³⁴⁵,Bardelang David⁷⁸⁹¹⁰¹¹,Zheng Jun⁶³⁴⁵,Yew Wing Wai¹²¹³⁵,Chan Denise Pui-Chung¹²¹³⁵,Lee Simon Ming Yuen¹²³⁴⁵,Wang Ruibing¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Quality Research in Chinese Medicine

2. Institute of Chinese Medical Sciences

3. University of Macau

4. Taipa

5. China

6. Faculty of Health Sciences

7. Aix-Marseille Université

8. CNRS

9. Institut de Chimie Radicalaire

10. UMR 7273

11. 13013 Marseille

12. Stanley Ho Centre for Emerging Infectious Diseases

13. The Chinese University of Hong Kong

Abstract

We demonstrate for the first time that cucurbit[7]uril effectively increased the water-solubility and decreased cardiotoxicity of clofazimine.

Funder

Universidade de Macau

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB01060A

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