Catalytic and highly regenerable aminic organoselenium antioxidants with cytoprotective effects

Author:

Kumar Manish1234ORCID,Chhillar Babli1234,Yadav Manisha1234,Sagar Poonam5674,Singhal Nitin K.5674ORCID,Gates Paul J.891011ORCID,Butcher Ray J.12131415ORCID,Singh Vijay P.1234ORCID

Affiliation:

1. Department of Chemistry & Centre of Advanced Studies in Chemistry

2. Panjab University

3. Chandigarh-160 014

4. India

5. Department of Biotechnology

6. National Agri-Food Biotechnology Institute

7. Mohali 160071

8. School of Chemistry

9. University of Bristol

10. Bristol

11. UK

12. Howard University

13. Department of Chemistry

14. Washington

15. USA

Abstract

N-Methyl ebselenamines carrying an aminic group in very close proximity to selenium as excellent chain-breaking and glutathione peroxidase-like antioxidants could reduce the production of ROS in C6 astroglial cell lines with minimal toxic effects.

Funder

University Grants Commission

Council of Scientific and Industrial Research

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference56 articles.

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3. Mitochondrial Oxidative Stress: Implications for Cell Death

4. M. G. J. Pokorny and N.Yanishlieva , Antioxidants in Foods , Woodhead Publishing , Cambridge , 2001

5. Chemistry and Technology of Lubricants , ed. S. T. Orszulik and R. M. Mortier , Blackie Academic & Professional , London , 1997

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