Corallopyronin A: antimicrobial discovery to preclinical development

Author:

Krome Anna K.123ORCID,Becker Tim12,Kehraus Stefan24,Schiefer Andrea23,Gütschow Michael5ORCID,Chaverra-Muñoz Lillibeth6ORCID,Hüttel Stephan6,Jansen Rolf6,Stadler Marc67ORCID,Ehrens Alexandra23,Pogorevc Domen78ORCID,Müller Rolf78ORCID,Hübner Marc P.23ORCID,Hesterkamp Thomas9,Pfarr Kenneth23ORCID,Hoerauf Achim23,Wagner Karl G.12ORCID,König Gabriele M.24ORCID

Affiliation:

1. Pharmaceutical Technology and Biopharmaceutics, University of Bonn, Germany

2. German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Germany

3. Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Germany

4. Institute for Pharmaceutical Biology, University of Bonn, Germany

5. Pharmaceutical & Medicinal Chemistry, University of Bonn, Germany

6. Department of Microbial Drugs, Helmholtz Centre for Infection Research, Braunschweig, Germany

7. German Center for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Germany

8. Helmholtz Institute for Pharmaceutical Research Saarland, Saarbrucken, Germany

9. Translational Project Management Office (TPMO), German Center for Infection Research (DZIF), Braunschweig, Germany

Abstract

Identifying new antibiotics and their further development is a priority of natural product research. The antibiotic corallopyronin A serves in this review as a show case for the development of a naturally occurring antibiotic compound.

Funder

Bundesministerium für Bildung und Forschung

Deutsches Zentrum für Infektionsforschung

European Regional Development Fund

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

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