Impact of the central atom and halido ligand on the structure, antiproliferative activity and selectivity of half-sandwich Ru(<scp>ii</scp>) and Ir(<scp>iii</scp>) complexes with a 1,3,4-thiadiazole-based ligand-Reference-Cited by-同舟云学术

Impact of the central atom and halido ligand on the structure, antiproliferative activity and selectivity of half-sandwich Ru(ii) and Ir(iii) complexes with a 1,3,4-thiadiazole-based ligand

Published:2023 Issue:36 Volume:52 Page:12717-12732
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Křikavová Radka¹^ORCID,Romanovová Michaela²,Jendželovská Zuzana²,Majerník Martin²,Masaryk Lukáš¹,Zoufalý Pavel¹,Milde David³^ORCID,Moncol Jan⁴^ORCID,Herchel Radovan¹^ORCID,Jendželovský Rastislav²,Nemec Ivan¹⁵^ORCID

Affiliation:

1. Department of Inorganic Chemistry, Faculty of Science, Palacký University Olomouc, 17. listopadu 12, CZ-771 46 Olomouc, Czech Republic

2. Department of Cellular Biology, Institute of Biology and Ecology, Faculty of Science, Pavol Jozef Šafárik University in Košice, Šrobárova 2, 041 54 Košice, Slovakia

3. Department of Analytical Chemistry, Faculty of Science, Palacký University Olomouc, 17. listopadu 12, CZ-771 46 Olomouc, Czech Republic

4. Department of Inorganic Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava, Bratislava SK-81237, Slovakia

5. Central European Institute of Technology, Brno University of Technology, Purkyňova 123, 61200 Brno, Czech Republic

Abstract

Cancer cell selective antiproliferative activity of thiadiazole-based half-sandwich complexes in sensitive and resistant ovarian cancer cell lines is triggered by exchanging Ru for Ir and by switching the halido coligand from chloride to iodide.

Funder

Univerzita Palackého v Olomouci

Agentúra na Podporu Výskumu a Vývoja

European Regional Development Fund

Vedecká Grantová Agentúra MŠVVaŠ SR a SAV

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/DT/D3DT01696J

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5. Half-Sandwich Ir(III) and Os(II) Complexes of Pyridyl-Mesoionic Carbenes as Potential Anticancer Agents

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