A cheap metal for a challenging task: nickel-catalyzed highly diastereo- and enantioselective hydrogenation of tetrasubstituted fluorinated enamides-Reference-Cited by-同舟云学术

A cheap metal for a challenging task: nickel-catalyzed highly diastereo- and enantioselective hydrogenation of tetrasubstituted fluorinated enamides

Published:2019 Issue:1 Volume:10 Page:252-256
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Guan Yu-Qing¹²³⁴⁵,Han Zhengyu¹²³⁴⁵,Li Xiuxiu¹²³⁴⁵,You Cai¹²³⁴⁵,Tan Xuefeng⁶⁷⁸⁹⁵,Lv Hui¹²³⁴⁵^ORCID,Zhang Xumu⁶⁷⁸⁹⁵^ORCID

Affiliation:

1. Key Laboratory of Biomedical Polymers of Ministry of Education

2. College of Chemistry and Molecular Sciences

3. Wuhan University

4. Wuhan

5. P. R. China

6. Department of Chemistry

7. Shenzhen Grubbs Institute

8. Southern University of Science and Technology

9. Shenzhen

Abstract

Nickel-catalyzed stereospecific syn-selective asymmetric hydrogenation of challenging tetrasubstituted fluorinated enamides has been achieved. This protocol provides an efficient access to chiral α-fluoro-β-amino esters.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Hubei Province

Ministry of Education of the People's Republic of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/SC/C8SC04002H

Reference74 articles.

1. Asymmetric hydrogenation

2. Asymmetric Transfer Hydrogenation Catalyzed by Chiral Ruthenium Complexes

3. Recoverable Catalysts for Asymmetric Organic Synthesis

4. New Chiral Phosphorus Ligands for Enantioselective Hydrogenation

5. On the Mechanism of Stereoselection in Rh-Catalyzed Asymmetric Hydrogenation: A General Approach for Predicting the Sense of Enantioselectivity

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