Novel pyrrolidine-2,4-dione derivatives containing pharmacophores of both hydrazine and diphenyl ether as potential antifungal agents: design, synthesis, biological evaluation, and 3D-QSAR study-Reference-Cited by-同舟云学术

Novel pyrrolidine-2,4-dione derivatives containing pharmacophores of both hydrazine and diphenyl ether as potential antifungal agents: design, synthesis, biological evaluation, and 3D-QSAR study

Published:2020 Issue:46 Volume:44 Page:20071-20082
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Hu Hao-Ran¹²³⁴,Wang An¹²³⁴,Qiu Ling-Ling¹²³⁴,Wang Xiao-Bin¹²³⁴,Chen Min¹²³⁴⁵,Lu Ai-Min¹²³⁴⁵,Yang Chun-Long¹²³⁴⁵^ORCID

Affiliation:

1. Jiangsu Key Laboratory of Pesticide Science

2. Nanjing Agricultural University

3. Nanjing

4. P. R. China

5. Department of Chemistry, College of Sciences

Abstract

Novel pyrrolidine-2,4-dione derivatives were designed based on natural products. Some synthesized compounds showed excellent antifungal activity. Scanning electron microscopy was used to observe mycelium morphology. 3D-QSAR was also studied.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/NJ/D0NJ04551A

Reference46 articles.

1. Rethinking the importance of food quality in marine benthic food webs

2. The benefits of pesticides to mankind and the environment