Synthesis and cytotoxic evaluation of new terpenylpurines-Reference-Cited by-同舟云学术

Synthesis and cytotoxic evaluation of new terpenylpurines

Published:2016 Issue:107 Volume:6 Page:105412-105420
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Valles Elena¹²³⁴⁵,García Pablo A.¹²³⁴⁵,Miguel del Corral José Ma¹²³⁴⁵,Pérez Marta¹²³⁴⁵,Ferreira Isabel C. F. R.⁶⁷⁸⁹¹⁰,Calhelha Ricardo C.⁶⁷⁸⁹¹⁰,San Feliciano Arturo¹²³⁴⁵,Castro Ma Ángeles¹²³⁴⁵

Affiliation:

1. Departamento de Ciencias Farmacéuticas

2. Sección de Química Farmacéutica

3. Facultad de Farmacia

4. CIETUS-IBSAL

5. Universidad de Salamanca

6. Centro de Investigação de Montanha (CIMO)

7. Escola Superior Agrária

8. Instituto Politécnico de Bragança

9. 5300-253 Bragança

10. Portugal

Abstract

New 7/9-terpenylpurines were synthesized and evaluated as cytotoxics. Those derived from the natural compounds trans-communic and cupressic acids, showed GI₅₀ at the μM level.

Funder

Fundação para a Ciência e a Tecnologia

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA24254E

Reference28 articles.

1. The Chemodiversity of Purine as a Constituent of Natural Products

2. The purines: Potent and versatile small molecule inhibitors and modulators of key biological targets

3. Synthesis and biological activities of marine terpene-adenine hybrids and synthetic analogs