Development of Cu(<scp>ii</scp>)-specific peptide shuttles capable of preventing Cu–amyloid beta toxicity and importing bioavailable Cu into cells-Reference-Cited by-同舟云学术

Development of Cu(ii)-specific peptide shuttles capable of preventing Cu–amyloid beta toxicity and importing bioavailable Cu into cells

Published:2022 Issue:40 Volume:13 Page:11829-11840
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Okafor Michael¹²^ORCID,Gonzalez Paulina¹,Ronot Pascale³,El Masoudi Islah³,Boos Anne³,Ory Stéphane²^ORCID,Chasserot-Golaz Sylvette²,Gasman Stéphane²,Raibaut Laurent¹^ORCID,Hureau Christelle⁴,Vitale Nicolas²^ORCID,Faller Peter¹^ORCID

Affiliation:

1. Laboratory of Biometals and Biological Chemistry, Institut de Chimie (UMR 7177), Université de Strasbourg-CNRS, 4 Rue Blaise Pascal, 67000 Strasbourg, France

2. Centre National de la Recherche Scientifique, Université de Strasbourg, Institut des Neurosciences Cellulaires et Intégratives, F-67000 Strasbourg, France

3. Université de Strasbourg, CNRS, IPHC, UMR 7178, F-67000 Strasbourg, France

4. LCC-CNRS, Université de Toulouse, CNRS, Toulouse, France

Abstract

The synthetic peptide AKH-αR5W4NBD was designed as a shuttle to counteract copper imbalance in Alzheimer’s disease. In vitro, this shuttle is able to abstract Cu(ii) selectively from amyloid-β and transport it into cells in a bioavailable form.

Funder

H2020 European Research Council

Agence Nationale de la Recherche

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC02593K

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