Methotrexate-conjugated mPEG–PCL copolymers: a novel approach for dual triggered drug delivery-Reference-Cited by-同舟云学术

Methotrexate-conjugated mPEG–PCL copolymers: a novel approach for dual triggered drug delivery

Published:2018 Issue:8 Volume:42 Page:5937-5945
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Rostamizadeh Kobra¹²³,Manafi Mostafa¹²³,Nosrati Hamed⁴²³^ORCID,Kheiri Manjili Hamidreza¹²³,Danafar Hossein¹²³⁴²^ORCID

Affiliation:

1. Zanjan Pharmaceutical Nanotechnology Research Center, Zanjan University of Medical Sciences

2. Zanjan

3. Iran

4. Department of Pharmaceutical Biomaterials, School of Pharmacy, Zanjan University of Medical Sciences

Abstract

A conjugate of the antitumor drug, methotrexate (MTX), with a diblock methoxypoly(ethylene glycol)–poly(caprolactone) (mPEG–PCL) copolymer was synthesized by the reaction of the mPEG–PCL copolymer with MTX in the presence of dicyclohexylcarbodiimide and dimethylaminopyridine.

Funder

Zanjan University of Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/NJ/C7NJ04864E

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