Probing cytochrome P450-mediated activation with a truncated azinomycin analogue
Author:
Affiliation:
1. Institute of Cancer Therapeutics
2. University of Bradford
3. UK
4. State Key Laboratory of Silkworm Genome Biology
5. Southwest University
6. Chongqing
7. China
8. School of Pharmacy
9. University of East Anglia
10. Norwich NR4 7TJ
Abstract
Selective cytochrome P450 bioactivation of truncated azinomycin.
Funder
Yorkshire Cancer Research
Publisher
Royal Society of Chemistry (RSC)
Subject
Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2015/MD/C4MD00411F
Reference23 articles.
1. Cellular Effects Induced by the Antitumor Agent Azinomycin B
2. Azinomycins A and B, new antitumor antibiotics. III. Antitumor activity.
3. Azinomycins A and B, new antitumor antibiotics. I Producing organism, fermentation, isolation, and characterization.
4. Azinomycins A and B, new antitumor antibiotics. II Chemical structures.
5. Studies on the Mechanism of Action of Azinomycin B: Definition of Regioselectivity and Sequence Selectivity of DNA Cross-Link Formation and Clarification of the Role of the Naphthoate
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