Facile construction of pyrrolo[1,2-b]isoquinolin-10(5H)-ones via a redox-amination–aromatization–Friedel–Crafts acylation cascade reaction and discovery of novel topoisomerase inhibitors-Reference-Cited by-同舟云学术

Facile construction of pyrrolo[1,2-b]isoquinolin-10(5H)-ones via a redox-amination–aromatization–Friedel–Crafts acylation cascade reaction and discovery of novel topoisomerase inhibitors

Published:2016 Issue:61 Volume:52 Page:9593-9596
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Wu Shanchao¹²³⁴⁵,Liu Na¹²³⁴⁵,Dong Guoqiang¹²³⁴⁵,Ma Lin¹²³⁴⁵,Wang Shengzheng¹²³⁴⁵,Shi Wencai⁶⁷³⁴⁵,Fang Kun¹²³⁴⁵,Chen Shuqiang¹²³⁴⁵,Li Jian²⁸⁹⁵,Zhang Wannian¹²³⁴⁵,Sheng Chunquan¹²³⁴⁵,Wang Wei²⁸⁹⁵¹⁰

Affiliation:

1. Department of Medicinal Chemistry

2. School of Pharmacy

3. Second Military Medical University

4. Shanghai 200433

5. P. R. China

6. Department of Clinical Nutrition

7. Changhai Hospital

8. East China University of Science and Technology

9. Shanghai 200237

10. Department of Chemistry and Chemical Biology

Abstract

The new title compounds with uncovered topoisomerase inhibitory activities are efficiently constructed via a redox-amination–aromatization–Friedel–Crafts acylation cascade reaction.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2016/CC/C6CC03071H

Reference19 articles.

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3. Directed ortho metallation of tertiary aromatic amides

4. Tandem Cyclisations of Amidyl Radicals Derived from O-Acyl Hydroxamic Acid Derivatives

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