Hydroxyapatite nanoparticles induced calcium overload-initiated cancer cell-specific apoptosis through inhibition of PMCA and activation of calpain-Reference-Cited by-同舟云学术

Hydroxyapatite nanoparticles induced calcium overload-initiated cancer cell-specific apoptosis through inhibition of PMCA and activation of calpain

Published:2023 Issue:32 Volume:11 Page:7609-7622
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Dong Xiulin¹,Zang Chunyu¹,Sun Yi¹,Zhang Shuiquan²,Liu Changsheng²,Qian Jiangchao¹^ORCID

Affiliation:

1. State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China

2. Frontiers Science Center for Materiobiology and Dynamic Chemistry, East China University of Science and Technology, Shanghai 200237, P. R. China

Abstract

Intracellular degradation of HAPNs and inhibition of PMCA activity jointly contributed to calcium overload in tumor cells, which then activated calpain-mediated mitochondrial apoptosis pathways, resulting in cancer cell-specific toxicity.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2023/TB/D3TB00542A

Reference43 articles.

1. Bioceramics of calcium orthophosphates

2. Hydrothermal fabrication of porous hollow hydroxyapatite microspheres for a drug delivery system

3. An overview of graphene-based hydroxyapatite composites for orthopedic applications

4. A review on hydroxyapatite coatings for the biomedical applications: experimental and theoretical perspectives

5. Hydroxyapatite nanoparticles in situ grown on carbon nanotube as a reinforcement for poly (ε-caprolactone) bone scaffold