Phenotype-based discovery of a HeLa-specific cytotoxic molecule that downregulates HPV-mediated signaling pathwaysviaoxidative damage-Reference-Cited by-同舟云学术

Phenotype-based discovery of a HeLa-specific cytotoxic molecule that downregulates HPV-mediated signaling pathwaysviaoxidative damage

Published:2019 Issue:31 Volume:17 Page:7388-7397
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Lee Sanghee¹²³⁴⁵^ORCID,Cho Wansang⁶⁷⁸⁹⁵^ORCID,Hong Sungyoul¹⁰⁸⁹⁵,Yi Sihyeong⁶⁷⁸⁹⁵^ORCID,Kim Heejun⁶⁷⁸⁹⁵,Baek Soo Yeon¹²³⁴⁵,Park Hankum⁶⁷⁸⁹⁵^ORCID,Jung Jinjoo⁶⁷⁸⁹⁵,Shin Young Kee¹⁰⁸⁹⁵,Park Seung Bum⁶⁷⁸⁹⁵^ORCID

Affiliation:

1. Center for Neuro-Medicine

2. Brain Science Institute

3. Korea Institute of Science and Technology

4. Seoul 02792

5. Korea

6. CRI Center for Chemical Proteomics

7. Department of Chemistry

8. Seoul National University

9. Seoul 08826

10. Department of Pharmacy

Abstract

Selective bioactive compounds have emerged as major players in chemical biology for their potential in disrupting diverse biological pathways with minimal adverse effects.

Funder

National Research Foundation of Korea

Korea Institute of Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C9OB01341E

Reference33 articles.

1. Exploring biology with small organic molecules

2. New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

3. Chemistry: Chemical con artists foil drug discovery

4. Clinical development success rates for investigational drugs

5. Discovery of a Potent Inhibitor Class with High Selectivity toward Clostridial Collagenases

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