Regioselective 1,4- over 1,2-addition of 3,3-bis(silyl) allyloxy lithium to enals, enones and enoates. The remarkable α-effect of silicon-Reference-Cited by-同舟云学术

Regioselective 1,4- over 1,2-addition of 3,3-bis(silyl) allyloxy lithium to enals, enones and enoates. The remarkable α-effect of silicon

Published:2014 Issue:19 Volume:12 Page:3021-3025
ISSN:1477-0520
Container-title:Org. Biomol. Chem.
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Ye Xincui¹²³⁴,Sun Xianwei¹²³⁴,Huang Zhenggang¹²³⁴,Yang Na⁵⁶⁷⁴,Su Zhishan⁵⁶⁷⁴,Hu Changwei⁵⁶⁷⁴,Song Zhenlei¹²³⁴⁸

Affiliation:

1. Key laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry

2. West China School of Pharmacy

3. Sichuan University

4. Chengdu, China

5. Key Laboratory of Green Chemistry & Technology

6. Ministry of Education

7. College of Chemistry Sichuan University

8. State Key Laboratory of Biotherapy

Abstract

The remarkable α-effect of silicon leads to a regioselective 1,4- over 1,2-addition of 3,3-bis(silyl) allyloxy lithium to α,β-unsaturated carbonyl compounds.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/OB/C4OB00139G

Reference54 articles.

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3. ?,?-Unsaturated Carbonyl Compounds with Sterically Protected Carbonyl Groups?Enforced a3versus a1 Reactivity

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