New diterpene lactone derivatives from <i>Aphanamixis polystachya</i> leaves inhibit nitric oxide production in RAW 264.7 cells-Reference-Cited by-同舟云学术

New diterpene lactone derivatives from Aphanamixis polystachya leaves inhibit nitric oxide production in RAW 264.7 cells

Published:2024 Issue:29 Volume:14 Page:20536-20542
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Bang Ngo Anh¹²,Hai Yen Duong Thi¹,Thuy Hang Dan Thi¹,Yen Pham Hai¹,Hoang Nguyen Huy¹,Trang Do Thi¹,Dung Duong Thi¹,Cuc Nguyen Thi¹,Cuong Nguyen The³,Nhiem Nguyen Xuan¹²,Tai Bui Huu¹²,Van Kiem Phan¹²^ORCID

Affiliation:

1. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

2. Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

3. Institute of Ecology and Biological Resources, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

Abstract

Five new acyclic diterpene lactone derivatives containing two rare structural fragments a γ/δ-lactone and a furan-3-one from Aphanamixis polystachya. They inhibited NO production in LPS activated RAW264.7 cells with IC50 values of 16.8–37.7 μM.

Funder

Vietnam Academy of Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA02968B

Reference18 articles.

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2. Triterpenoids from the fruits of Aphanamixis polystachya and their inhibitory activities on nitric oxide production

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4. Diverse prieurianin-type limonoids with oxygen-bridged caged skeletons from two Aphanamixis species: discovery and biomimetic conversion

5. Aphananoid A is an Anti-Inflammatory Limonoid with a New 5/6/5 Fused Ring Featuring a C24 Carbon Skeleton from Aphanamixis polystachya