Identification, cloning, expression and functional interrogation of the biosynthetic pathway of the polychlorinated triphenyls ambigol A–C from Fischerella ambigua 108b-Reference-Cited by-同舟云学术

Identification, cloning, expression and functional interrogation of the biosynthetic pathway of the polychlorinated triphenyls ambigol A–C from Fischerella ambigua 108b

Published:2020 Issue:20 Volume:7 Page:3193-3201
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Duell Elke R.¹²³⁴⁵^ORCID,Milzarek Tobias M.¹²³⁴⁵^ORCID,El Omari Mustafa⁶⁷⁸⁵,Linares-Otoya Luis J.⁹¹⁰¹¹⁵¹²,Schäberle Till F.⁹¹⁰¹¹⁵¹²^ORCID,König Gabrielle M.⁶⁷⁸⁵^ORCID,Gulder Tobias A. M.¹²³⁴⁵^ORCID

Affiliation:

1. Biosystems Chemistry

2. Department of Chemistry and Center for Integrated Protein Science Munich (CIPSM)

3. Technical University of Munich

4. 85748 Garching

5. Germany

6. Institute for Pharmaceutical Biology

7. University of Bonn

8. 53115 Bonn

9. Institute for Insect Biotechnology

10. Justus Liebig University of Giessen

11. 35392 Giessen

12. Department of Bioresources

Abstract

The biosynthetic pathway to the ambigols A–C from Fischerella ambigua 108b has been identified, cloned, heterologously expressed and functionally studied, including in-depth analysis of the biaryl coupling biochemistry in vivo and in vitro.

Funder

Deutsche Bundesstiftung Umwelt

Stiftung der Deutschen Wirtschaft

Max-Buchner-Forschungsstiftung

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/QO/D0QO00707B

Reference51 articles.