Bioanalysis of riluzole in human plasma by a sensitive LC-MS/MS method and its application to a pharmacokinetic study in South Indian subjects

Author:

Narapusetti Anjaneyulu12345,Bethanabhatla Syama Sundar678,Sockalingam Anbazhagan91011,Pilli Nageswara Rao121314,Repaka Nagakishore4515,Alla Tejasri91617

Affiliation:

1. Department of Pharmaceutical Sciences

2. Jawaharlal Nehru Technological University Kakinada

3. Kakinada-533 003, India

4. Department of Pharmaceutical Analysis and Pharmacology

5. Geethanjali College of Pharmacy

6. Department of Chemistry

7. Yogi Vemana University

8. Kadapa-516 003, India

9. Department of Pharmaceutical Chemistry

10. Surya School of Pharmacy

11. Villupuram-605 652, India

12. Center for Pharmaceutical Sciences

13. Jawaharlal Nehru Technological University

14. Hyderabad-500 085, India

15. Cheeryal-501 301, India

16. Holly Mary Institute of Technology & Science College of Pharmacy

17. Bogaram-501 301, India

Abstract

In this paper, the authors proposed a simple, rapid and highly sensitive liquid chromatography-tandem mass spectrometric (LC-MS/MS) assay method for the determination of riluzole in human plasma.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Chemical Engineering,Analytical Chemistry

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