Tumor extracellular pH-sensitive polymeric nanocarrier-grafted platinum(iv) prodrugs for improved intracellular delivery and cytosolic reductive-triggered release-Reference-Cited by-同舟云学术

Tumor extracellular pH-sensitive polymeric nanocarrier-grafted platinum(iv) prodrugs for improved intracellular delivery and cytosolic reductive-triggered release

Published:2020 Issue:12 Volume:11 Page:2212-2221
ISSN:1759-9954
Container-title:Polymer Chemistry
language:en
Short-container-title:Polym. Chem.

Author:

Chen Sheng-Qi¹²³⁴⁵^ORCID,Song Gang¹²³⁴⁵,He Chen⁶⁷⁵,Hou Mei¹²³⁴⁵,He Wei-Dong⁸⁹¹⁰⁴⁵^ORCID,Li Hui-Juan⁸⁹¹⁰⁴⁵,Haleem Abdul⁸⁹¹⁰⁴⁵,Li Qing-Lin¹²³⁴⁵,Hu Rong-Feng¹²³⁴⁵

Affiliation:

1. Key Laboratory of Xin'an Medicine

2. Ministry of Education; Engineering Technology Research Center of Modernized Pharmaceutics

3. Anhui Province; Anhui University of Chinese Medicine

4. Hefei

5. China

6. Institute of Aerospace Materials and Processing

7. Beijing 100076

8. CAS Key Laboratory of Soft Matter Chemistry

9. Department of Polymer Science and Engineering

10. University of Science and Technology of China

Abstract

Extracellular pH-sensitive Pt(iv)-based nanodrugs enable preferential toxicity to tumor cells via a selectively endocytosed and triggered drug release strategy.

Funder

Natural Science Foundation of Anhui Province

National Natural Science Foundation of China

Anhui University of Chinese Medicine

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Polymers and Plastics,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2020/PY/C9PY01838G

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1. Cisplatin: The first metal based anticancer drug