Efficient synthesis of isoindolones by intramolecular cyclisation of pyridinylbenzoic acids-Reference-Cited by-同舟云学术

Efficient synthesis of isoindolones by intramolecular cyclisation of pyridinylbenzoic acids

Published:2021 Issue:37 Volume:19 Page:8025-8029
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Solea Atena B.¹²^ORCID,Wang Sining³^ORCID,Xue Xiao-Song³,Crochet Aurelien²^ORCID,Fromm Katharina M.²^ORCID,Houk Kendall N.³^ORCID,Mamula Olimpia¹^ORCID,Allemann Christophe¹^ORCID

Affiliation:

1. University of Applied Sciences of Western Switzerland, HES-SO, HEIA-FR, Pérolles 80, CH-1705 Fribourg, Switzerland

2. University of Fribourg, Department of Chemistry, Chemin du Musée 9, CH-1700 Fribourg, Switzerland

3. Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA

Abstract

Instead of anhydrides, isoindolones are formed in excellent yields by the deprotonation and tosylation of 2-pyridinylbenzoic acids. The mechanism of this new intramolecular cyclisation has been studied by DFT calculations.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB01343B

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