Fucoidan enhances the anti-tumor effect of anti-PD-1 immunotherapy by regulating gut microbiota-Reference-Cited by-同舟云学术

Fucoidan enhances the anti-tumor effect of anti-PD-1 immunotherapy by regulating gut microbiota

Published:2024 Issue:7 Volume:15 Page:3463-3478
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Li Hui¹^ORCID,Dong Tieying¹,Tao Meng¹,Zhao Haifeng²,Lan Tongtong¹,Yan Shiyu¹,Gong Xinyi¹,Hou Qilong¹,Ma Xuezhen³,Song Yang¹^ORCID

Affiliation:

1. Department of Nutrition and Food Hygiene, College of Medicine, Qingdao University, Qingdao, China

2. Qingdao Institute of Food and Drug Inspection, NMPA Key Laboratory for Quality Research and Evaluation of Traditional Marine Chinese, Medicine, China

3. The Affiliated Qingdao Central Hospital of Qingdao University, The Second Affiliated Hospital of Medical College of Qingdao University, Qingdao, China

Abstract

Fucoidan potentiated the antitumour effect with anti-PD-1 monoclonal antibody via enhancing CD8 T cells function, increasing the production of IFN-γ, TNF-α, and GZMB and reducing the suppression effect of Treg in circulating system, which might be addressed by reshaping gut microbiota.

Funder

Natural Science Foundation of Shandong Province

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/FO/D3FO04807A

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