Metal-free 18F-labeling of aryl-CF2H via nucleophilic radiofluorination and oxidative C

Metal-free 18F-labeling of aryl-CF2H via nucleophilic radiofluorination and oxidative C–H activation

Published:2017 Issue:1 Volume:53 Page:126-129
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Yuan Gengyang¹²³⁴⁵,Wang Feng⁶⁷⁸⁹¹⁰,Stephenson Nickeisha A.¹²³⁴⁵,Wang Lu¹²³⁴⁵,Rotstein Benjamin H.¹²³⁴⁵,Vasdev Neil¹²³⁴⁵,Tang Pingping⁶⁷⁸⁹¹⁰,Liang Steven H.¹²³⁴⁵

Affiliation:

1. Gordon Center for Medical Imaging & Division of Nuclear Medicine and Molecular Imaging

2. Massachusetts General Hospital and Department of Radiology

3. Harvard Medical School

4. Boston

5. USA

6. State Key Laboratory and Institute of Elemento-Organic Chemistry

7. Nankai University

8. Collaborative Innovation Center of Chemical Science and Engineering

9. Tianjin

10. China

Abstract

A metal-free and selective method to form [¹⁸F]aryl-CF₂H through nucleophilic radiofluorination of benzyl (pseudo)halides and oxidative C–H activation of benzylic C–H bonds has been developed.

Funder

National Institute on Drug Abuse

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2017/CC/C6CC07913J

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