Antiviral activity of sulphated specialized metabolites from sea urchin Clypeaster humilis: in vitro and in silico studies

Author:

Abdelkarem Fahd M.1ORCID,Assaf Hamdy K.1ORCID,Mostafa Yaser A.23ORCID,Mahdy Aldoushy4,Hussein Modather F.56,Ross Samir A.78ORCID,Mohamed Nesma M.910ORCID

Affiliation:

1. Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, Egypt

2. Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt

3. Pharmaceutical Chemistry Department, Faculty of Pharmacy, Badr University, Assiut 77771, Egypt

4. Department of Zoology, Faculty of Science, Al-Azhar University, Assiut, 71524, Egypt

5. Chemistry Department, Collage of Science, Jouf University, P.O. Box 2014, Sakaka 72388, Saudi Arabia

6. Chemistry Department, Faculty of Science, Al-Azhar University, Asyut Branch, Assiut 71524, Egypt

7. National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, Mississippi 38677, USA

8. Department of BioMolecular Sciences, Division of Pharmacognosy, School of Pharmacy, University of Mississippi, Mississippi 38677, USA

9. Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt

10. Department of Pharmacognosy, Faculty of Pharmacy, Badr University, Assiut 77771, Egypt

Abstract

Chemical analyses of the sea urchin Clypeaster humilis yielded twelve compounds including; a new sulfonic acid derivative (7R) tridec-1-en-7-yl hydrogen sulphate (1), pyridine-3-yl methane sulfonate (2), boldine (12), and nine known compounds (3–11).

Funder

Ministry of Higher Education

University of Mississippi

Publisher

Royal Society of Chemistry (RSC)

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