Characterization and preliminaryin vivoevaluation of a self-expandable hydrogel stent with anisotropic swelling behavior and endoscopic deliverability for use in biliary drainage

Author:

Nagakawa Yoshiyasu12ORCID,Fujita Satoshi23ORCID,Yunoki Shunji1,Tsuchiya Takayoshi4,Suye Shin-ichiro23,Kinoshita Kenji5,Sasaki Motoki6,Itoi Takao4

Affiliation:

1. Biotechnology Group, Tokyo Metropolitan Industrial Technology Research Institute, 2-4-10, Aomi, Koto-ku, Tokyo, 135-0064, Japan

2. Department of Frontier Fiber Technology and Sciences, Graduate School of Engineering University of Fukui, 3-9-1, Bunkyo, Fukui, 910-8507, Japan

3. Life Science Innovation Center, University of Fukui, 3-9-1, Bunkyo, Fukui, 910-8507, Japan

4. Department of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1, Nishishinjuku, Shinjuku-ku, Tokyo, Japan

5. Industrial Analysis and Inspection Technology Group, Tokyo Metropolitan Industrial Technology Research Institute, 2-4-10, Aomi, Koto-ku, Tokyo, 135-0064, Japan

6. Division of Research and Development for Minimally Invasive Treatment, Cancer Center Keio University School of Medicine, 35, Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan

Abstract

We demonstrate the potential of a novel self-expandable biliary stent comprised of poly(vinyl alcohol) (PVA) hydrogel with anisotropic swelling behavior, endoscopic deliverability, and removabilityin vivo, using a porcine stent model.

Funder

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Reference52 articles.

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