K2S2O8-mediated radical cyclisation of 2-alkynylthioanisoles or -selenoanisoles: a green and regioselective route to 3-nitrobenzothiophenes and benzoselenophenes-Reference-Cited by-同舟云学术

K2S2O8-mediated radical cyclisation of 2-alkynylthioanisoles or -selenoanisoles: a green and regioselective route to 3-nitrobenzothiophenes and benzoselenophenes

Published:2020 Issue:32 Volume:10 Page:19083-19087
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Lu Shi-Chao¹²³⁴⁵^ORCID,Wu Botao⁶⁷⁸⁹,Zhang Shi-Peng¹²³⁴⁵,Gong Ya-Ling¹²³⁴⁵,Xu Shu¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines

2. and Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation

3. Institute of Materia Medica

4. Chinese Academy of Medical Sciences and Peking Union Medical College

5. Beijing 100050

6. College of Chemistry and Molecular Engineering

7. Peking University

8. Beijing 100871

9. P. R. China

Abstract

This is the first example of highly unstable 2-nitrovinyl radicals for C–S bond formation. The facile route efficiently functionalizes 3-nitrobenzothiophenes and benzoselenophenes, which are difficult to obtain by classical methods.

Funder

National Natural Science Foundation of China

Chinese Academy of Medical Sciences

Peking Union Medical College

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/RA/D0RA03894F

Reference33 articles.

1. Nitro-Group-Containing Drugs