Visualizing antithrombin-binding 3-O-sulfated heparan sulfate motifs on cell surfaces-Reference-Cited by-同舟云学术

Visualizing antithrombin-binding 3-O-sulfated heparan sulfate motifs on cell surfaces

Published:2020 Issue:92 Volume:56 Page:14423-14426
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Kalita Mausam¹²³⁴^ORCID,Chua Jie Shi¹²³⁴,Boothello Rio S.⁵⁶⁷⁸⁴^ORCID,Joice April¹²³⁴,Antelope Orlando¹²³⁴,Roy Anindita¹²³⁴,Anandh Babu Pon Velayutham⁹³⁴^ORCID,Saijoh Yukio¹⁰³⁴^ORCID,Desai Umesh R.⁵⁶⁷⁸⁴^ORCID,Kuberan Balagurunathan¹²³⁴^ORCID

Affiliation:

1. Departments of Medicinal Chemistry and Bioengineering

2. University of Utah

3. Salt Lake City

4. USA

5. Department of Medicinal Chemistry

6. School of Pharmacy

7. Virginia Commonwealth University

8. Richmond

9. Department of Nutrition and Integrative Physiology, University of Utah

10. Department of Neurobiology and Anatomy, University of Utah School of Medicine

Abstract

To map the cellular topography of the rare 3-O-sulfated structural motif of heparan sulfate (HS), we constructed quantum dot-based probes for antithrombin and FGF2, which reveal widely different distribution of the targeted HS motifs.

Funder

National Center for Complementary and Integrative Health

National Institute of Food and Agriculture

National Heart, Lung, and Blood Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CC/D0CC05893A

Reference35 articles.

1. Heparan sulphate proteoglycans fine-tune mammalian physiology

2. Anticoagulant and signaling functions of antithrombin

3. Combinatorial virtual library screening analysis of antithrombin binding oligosaccharide motif generation by heparan sulfate 3-O-Sulfotransferase 1

4. New antithrombin-based anticoagulants

5. Receptor tyrosine kinases and heparan sulfate proteoglycans: Interplay providing anticancer targeting strategies and new therapeutic opportunities

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