An ebselen like catalyst with enhanced GPx activity via a selenol intermediate-Reference-Cited by-同舟云学术

An ebselen like catalyst with enhanced GPx activity via a selenol intermediate

Published:2014 Issue:8 Volume:12 Page:1215-1219
ISSN:1477-0520
Container-title:Org. Biomol. Chem.
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Balkrishna Shah Jaimin¹²³,Kumar Shailesh¹²³,Azad Gajendra Kumar⁴²³,Bhakuni Bhagat Singh¹²³,Panini Piyush¹²³,Ahalawat Navjeet¹²³,Tomar Raghuvir Singh⁴²³,Detty Michael R.¹⁵⁶⁷,Kumar Sangit¹²³

Affiliation:

1. Department of Chemistry

2. Indian Institute of Science Education and Research Bhopal (IISER)

3. Bhopal, India

4. Department of Biological Sciences

5. University at Buffalo

6. The State University of New York

7. , USA

Abstract

Benzamide ring-substituted, quinine-derived ebselen analogue is synthesized which exists in selenol form upon addition of PhSH. It catalyses oxidation of PhSH with H₂O₂ faster (10³-fold) than ebselen.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/OB/C4OB00027G

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